"The dogma that the central nervous system cannot regenerate is simply not true; we just haven’t figured out how to make it happen yet."
These neurons, and their connections to the spinal cord, do not regenerate. To regenerate specific neurons, we must understand how they are generated in the first place. In other words, we believe that the key to achieving therapeutic regeneration is a clear understanding of development.
How genes are regulated to control corticospinal motor neuron development is just beginning to be understood. One way genes are regulated is by small, non-coding RNAs (microRNAs). Our lab has recently discovered that microRNAs appear to be critical to corticospinal motor neuron development. The members of my lab are investigating the ability of microRNAs to control corticospinal motor neuron development in the embryo, in immature brain cells in the dish, and in stem cells.
Why is this exciting?
Regulation by microRNAs represents an entirely new way of understanding the generation of these important neurons. If we can understand how neurons naturally develop, we will be able to identify targets to stimulate their regeneration.
1) Tharin Lab, University of Stanford
2) S.Tharin et al A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes. Integr Biol (Camb) Nov 2012
3) Iyer et al. Cervical Spondylotic Myelopathy. Clin Spine Surg. Jun 2016
Dr. Satkunendrarajah, from the Fehling's Lab Canada, is using animal models to understand how the electrical connections of the spinal cord are disrupted in CSM
What are you working on at the moment?
There is now evidence to show CSM patients are more likely to suffer breathing related illnesses, such as pneumonia and atelectasis (partial or complete collapse of the lung). (3) (4) This may correlate with the severity and level of cord compression.
Why does this excite you?
1. SK Karadimas et al. Riluzole blocks perioperative ischemia-reperfusion injury and enhances post decompression outcomes in cervical spondylotic myelopathy. Sci Trans Med 02 Dec 2015: 316ra194
2. SK Karadimas et al. A novel experimental model of cervical spondylotic myelopathy (CSM) to facilitate translational research. Neurobiol Dis. 2013 Jun;54:43-583. Toyoda, H et al. Does chronic cervical myelopathy affect respiratory function? J Neurosurg Spine 1:175-178.
4. Gelaye, A et al. Difficult-to-wean: High index of suspicion. Am J Case Rep 2014 15:163-167.
The latest expert and patient articles